Pub. Date : 2007 Apr 20
PMID : 16904808
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Presently, standard treatment includes administration of an antimuscarinic agent (e.g. atropine) and a reactivator of inhibited AChE (oxime), but is considered to be rather ineffective with certain nerve agents due to low oxime effectiveness of the currently available oximes, obidoxime and pralidoxime. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The model is based on a combination of enzyme kinetics (inhibition, reactivation, aging) of AChE with OP, toxicokinetics and oxime pharmacokinetics. | Oximes | acetylcholinesterase (Cartwright blood group) | Homo sapiens |