Title : Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells.

Pub. Date : 2006 Oct 6

PMID : 16904634






1 Functional Relationships(s)
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1 Combining TSA with PS-341 effectively inactivated NFkappaB signaling, downregulated the predominant endogenous anti-apoptotic factor Bcl-XL overexpression, and disrupted MAP kinase pathway. trichostatin A BCL2 like 1 Homo sapiens