Title : The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function.

Pub. Date : 2006 Dec 15

PMID : 16902152






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Tryptophan (Trp) catabolism mediated by indoleamine 2,3-dioxygenase (IDO) plays a central role in the regulation of T-cell-mediated immune responses. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
2 Tryptophan (Trp) catabolism mediated by indoleamine 2,3-dioxygenase (IDO) plays a central role in the regulation of T-cell-mediated immune responses. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
3 Tryptophan (Trp) catabolism mediated by indoleamine 2,3-dioxygenase (IDO) plays a central role in the regulation of T-cell-mediated immune responses. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
4 Tryptophan (Trp) catabolism mediated by indoleamine 2,3-dioxygenase (IDO) plays a central role in the regulation of T-cell-mediated immune responses. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
5 Indeed, l-kynurenine, a Trp-derived catabolite resulting from IDO activity, was found to prevent the cytokine-mediated up-regulation of the expression and function of specific triggering receptors responsible for the induction of NK-cell-mediated killing. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens