Title : Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast.

Pub. Date : 2006 Mar

PMID : 16897708






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Indoleamine 2,3-dioxygenase (IDO) is a tryptophan degradation enzyme that is emerging as an important drug target. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
2 We show that expression of human IDO in a Saccharomyces cerevisiae tryptophan auxotroph restricts yeast growth in the presence of low tryptophan concentrations and that inhibition of IDO activity can restore growth. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens
3 We show that expression of human IDO in a Saccharomyces cerevisiae tryptophan auxotroph restricts yeast growth in the presence of low tryptophan concentrations and that inhibition of IDO activity can restore growth. Tryptophan indoleamine 2,3-dioxygenase 1 Homo sapiens