Title : [Cancer and immunosuppression: pro- and antitumoral effects of immunosuppressive drugs].

Pub. Date : 2005 Mar

PMID : 16895664






1 Functional Relationships(s)
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1 Calcineurin inhibitors, cyclosporine and tacrolimus, are involved in tumor development through various mechanisms: they promote B-cell proliferation by increasing T lymphocyte IL6 secretion, decrease DNA repair ability and may be able to promote metastasis spreading by a direct cellular effect that is independent of their effect on the host"s immune cells. Tacrolimus interleukin 6 Homo sapiens