Title : Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation.

Pub. Date : 2006 Aug

PMID : 16895577






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The actin-binding protein gelsolin was identified as a mediator of neuroprotection by TSA. trichostatin A gelsolin Homo sapiens
2 TSA enhanced histone acetylation of the gelsolin promoter region, and up-regulated gelsolin messenger RNA and protein expression in a dose- and time-dependent manner. trichostatin A gelsolin Homo sapiens
3 TSA enhanced histone acetylation of the gelsolin promoter region, and up-regulated gelsolin messenger RNA and protein expression in a dose- and time-dependent manner. trichostatin A gelsolin Homo sapiens
4 The neuroprotective effect of TSA was completely abolished in neurons lacking gelsolin gene expression. trichostatin A gelsolin Homo sapiens