Title : Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation.

Pub. Date : 2006

PMID : 16893669






4 Functional Relationships(s)
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1 Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens
2 In addition, ERK 1/2 and p38 MAPK were activated by ATP in a dose- and time-dependent manner. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens
3 Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens
4 Altogether, these results represent the first evidence to date suggesting that P2Y(2) receptor stimulation by ATP in osteoblasts sensitizes mechanical stress activated calcium channels leading to calcium influx and a fast activation of the ERK 1/2 and p38 MAPK pathways. Adenosine Triphosphate mitogen-activated protein kinase 1 Homo sapiens