Pub. Date : 2006
PMID : 16893669
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
2 | In addition, ERK 1/2 and p38 MAPK were activated by ATP in a dose- and time-dependent manner. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
3 | Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |
4 | Altogether, these results represent the first evidence to date suggesting that P2Y(2) receptor stimulation by ATP in osteoblasts sensitizes mechanical stress activated calcium channels leading to calcium influx and a fast activation of the ERK 1/2 and p38 MAPK pathways. | Adenosine Triphosphate | mitogen-activated protein kinase 1 | Homo sapiens |