Title : Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib.

Pub. Date : 2006 Aug

PMID : 16890580






1 Functional Relationships(s)
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1 OBJECTIVE: Our objective was to explore the relationships between imatinib pharmacokinetics and 9 allelic variants in 7 genes coding for adenosine triphosphate-binding cassette transporters (ABCB1 and ABCG2) and enzymes (cytochrome P450 [CYP] 2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) of putative relevance for imatinib. Imatinib Mesylate cytochrome P450 family 3 subfamily A member 4 Homo sapiens