Title : Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.

Pub. Date : 2006 Aug 1

PMID : 16885361






1 Functional Relationships(s)
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1 Hamster fibroblasts expressing a mutation in SDH subunit C (SDHC; B9) showed 3-fold increases in dihydroethidine and dichlorodihydrofluorescein (CDCFH(2)) oxidation indicative of increased steady-state levels of O2(.-) and H2O2, increases in glutathione/glutathione disulfide (indicative of oxidative stress), as well as increases in superoxide dismutase activity, relative to parental B1 cells. Hydrogen Peroxide succinate dehydrogenase complex iron sulfur subunit B Homo sapiens