Title : Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line.

Pub. Date : 2007 Mar

PMID : 16884772






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We identified in FPGS from CEM-p cells three amino acid substitutions that altered the ATP binding P-loop, glutamate/folate binding, and a conserved domain located at the carboxyl-terminal. Folic Acid folylpolyglutamate synthase Homo sapiens