Pub. Date : 2006 Sep 18
PMID : 16884712
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 7 | However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 8 | However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |
| 9 | These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner. | Dizocilpine Maleate | brain-derived neurotrophic factor | Rattus norvegicus |