Title : Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.

Pub. Date : 2006 Nov

PMID : 16882766






7 Functional Relationships(s)
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1 The metabolism of arylhydrazines by cytochromes P450 (P450s) has previously been shown to yield aryl-iron complexes that inhibit P450 enzymes as a result of heme modification. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 The metabolism of arylhydrazines by cytochromes P450 (P450s) has previously been shown to yield aryl-iron complexes that inhibit P450 enzymes as a result of heme modification. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 The metabolism of arylhydrazines by cytochromes P450 (P450s) has previously been shown to yield aryl-iron complexes that inhibit P450 enzymes as a result of heme modification. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
4 These modifications of the heme have been used to probe the topology of the active site of several P450s. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
5 Analysis of the P450 heme from P450s inactivated by the five substituted diaziridines suggested that the activity loss was not due to heme destruction as measured by the reduced-CO spectrum or high-performance liquid chromatography of the P450 heme. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
6 Analysis of the P450 heme from P450s inactivated by the five substituted diaziridines suggested that the activity loss was not due to heme destruction as measured by the reduced-CO spectrum or high-performance liquid chromatography of the P450 heme. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens
7 Analysis of the P450 heme from P450s inactivated by the five substituted diaziridines suggested that the activity loss was not due to heme destruction as measured by the reduced-CO spectrum or high-performance liquid chromatography of the P450 heme. Heme cytochrome P450 family 2 subfamily B member 6 Homo sapiens