Title : Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6.

Pub. Date : 2006 Nov

PMID : 16882766






1 Functional Relationships(s)
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1 Five of the six trifluoroaryldiaziridines tested selectively inactivated P450 2B6 in the reconstituted system in a time-, concentration-, and NADPH-dependent manner as measured using the 7-ethoxy-4-(trifluoromethyl)coumarin O-deethylation assay. NADP cytochrome P450 family 2 subfamily B member 6 Homo sapiens