Title : Protection from experimental colitis by theaflavin-3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation.

Pub. Date : 2006 Sep

PMID : 16880762






2 Functional Relationships(s)
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1 DNA binding and Western blotting revealed increase in NF-kappaB activation and IkappaBalpha depletion in TNBS-treated mice from Day 2 through Day 8 with a maximum at Day 4, which resulted from increased phosphorylation of IkappaBalpha and higher activity of IkappaB kinase (IKK). Trinitrobenzenesulfonic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Pretreatment with TFDG markedly inhibited TNBS-induced increases in nuclear localization of NF-kappaB, cytosolic IKK activity and preserved IkappaBalpha in colon tissue. Trinitrobenzenesulfonic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus