Pub. Date : 2007 Jan
PMID : 16874462
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). | Proline | proline dehydrogenase 1 | Homo sapiens |
| 2 | Proline oxidase (POX), a mitochondrial inner-membrane protein, catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). | Proline | proline dehydrogenase 1 | Homo sapiens |
| 3 | To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 4 | To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 5 | To further investigate the molecular basis of POX-induced apoptosis, we utilized the DLD-1.POX cells to show that cells overproducing POX exhibit an L-proline-dependent apoptotic response. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 6 | The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 7 | The apoptotic effect is specific for L-proline, detectable at 0.2 mM, maximal at 1 mM, and occurs during 48-72 h following the addition of L-proline to cells with maximally induced POX. | Proline | proline dehydrogenase 1 | Homo sapiens |
| 8 | We conclude that in the presence of proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis. | Proline | proline dehydrogenase 1 | Homo sapiens |