Title : ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival.

Pub. Date : 2006 Aug

PMID : 16873684






1 Functional Relationships(s)
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1 We observed that 10 mmol/l glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 micromol/l) and reduced by 50% with the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (20 micromol/l). N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide cAMP responsive element binding protein 1 Mus musculus