Title : P-glycoprotein restricts access of cortisol and dexamethasone to the glucocorticoid receptor in placental BeWo cells.

Pub. Date : 2006 Nov

PMID : 16873536






2 Functional Relationships(s)
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1 Studies in the rodent brain show that P-glycoprotein (P-gp) is also an important physiological regulator of glucocorticoid access to the glucocorticoid receptor (GR) in target cells because it exports cortisol back into peripheral circulation against a concentration gradient. Hydrocortisone ATP binding cassette subfamily B member 1 Homo sapiens
2 Studies in the rodent brain show that P-glycoprotein (P-gp) is also an important physiological regulator of glucocorticoid access to the glucocorticoid receptor (GR) in target cells because it exports cortisol back into peripheral circulation against a concentration gradient. Hydrocortisone ATP binding cassette subfamily B member 1 Homo sapiens