Title : Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.

Pub. Date : 2006 Aug

PMID : 16864673






3 Functional Relationships(s)
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1 Two paramagnetic myeloperoxidase substrates--that is, gadolinium-5-hydroxytryptamide-tetraazacyclododecane tetraacetic acid (Gd-5-HT-DOTA) and Gd-bis-5-HT-diethylenetriaminepentaacetic acid (Gd-bis-5-HT-DTPA)--were synthesized. gd-bis-5-ht-dtpa myeloperoxidase Homo sapiens
2 RESULTS: After the administration of Gd-bis-5-HT-DTPA, strong MR signal enhancement (up to 2.5-fold increase in CNR, P < .001) was observed in vivo for implants that contained human myeloperoxidase. gd-bis-5-ht-dtpa myeloperoxidase Homo sapiens
3 Prolonged contrast material enhancement was observed in the myeloperoxidase-containing areas that were injected with Gd-5-HT-DOTA or Gd-bis-5-HT-DTPA but was not observed in areas that were injected with Gd-DTPA or Gd-dopamine-DOTA (P < .05). gd-bis-5-ht-dtpa myeloperoxidase Homo sapiens