Title : Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.

Pub. Date : 2006 Sep 29

PMID : 16861223






1 Functional Relationships(s)
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1 X-ray crystallography of the complex of CD38 with one of its substrates, NMN, showed that the nicotinamide moiety was in close contact with Glu(146) at 3.27 A and Asp(155) at 2.52 A. Niacinamide CD38 molecule Homo sapiens