Title : The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects.

Pub. Date : 2006 Dec

PMID : 16856883






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1 The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects. Rosiglitazone cytochrome P450 family 2 subfamily C member 8 Homo sapiens
2 AIMS: To determine the effect of CYP2C8 genotype and of fluvoxamine on the pharmacokinetics of rosiglitazone. Rosiglitazone cytochrome P450 family 2 subfamily C member 8 Homo sapiens
3 CONCLUSION: The importance of the CYP2C8*3 mutation in the in vivo metabolism of rosiglitazone could not be confirmed. Rosiglitazone cytochrome P450 family 2 subfamily C member 8 Homo sapiens