Title : Regional differences of beta 1- and beta 2-adrenoceptor-mediated functions in feline heart. A beta 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP.

Pub. Date : 1991 Jul

PMID : 1685558






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR. Norepinephrine adrenoceptor beta 1 Homo sapiens
2 During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR. Norepinephrine adrenoceptor beta 1 Homo sapiens
3 Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR. Norepinephrine adrenoceptor beta 1 Homo sapiens
4 The positive inotropic effects of (-)-noradrenaline appeared to be nearly exclusively mediated through beta 1AR in right ventricular papillary muscles. Norepinephrine adrenoceptor beta 1 Homo sapiens