Title : Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages.

Pub. Date : 2006 Aug 7

PMID : 16847070






3 Functional Relationships(s)
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1 Consistent with a role for oxidative stress in this effect, in vitro H2O2 treatment of RAW 264.7 macrophages similarly caused an increase in surface TLR4. Hydrogen Peroxide toll like receptor 4 Homo sapiens
2 The H2O2-induced increase in surface TLR4 was prevented by depleting intracellular calcium or disrupting the cytoskeleton, suggesting the involvement of receptor exocytosis. Hydrogen Peroxide toll like receptor 4 Homo sapiens
3 Preventing the oxidant-induced movement of TLR4 to lipid rafts using methyl-beta-cyclodextrin precluded the increased responsiveness of cells to LPS after H2O2 treatment. Hydrogen Peroxide toll like receptor 4 Homo sapiens