Pub. Date : 2006 Sep
PMID : 16846619
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors. | Fluvoxamine | 5-hydroxytryptamine (serotonin) receptor 2A | Mus musculus |
| 2 | The antiallodynic effects of systemic fluvoxamine were also reduced by both systemic and intrathecal administration of ketanserin, a 5-HT2A/2C receptor antagonist. | Fluvoxamine | 5-hydroxytryptamine (serotonin) receptor 2A | Mus musculus |
| 3 | These results indicate that fluvoxamine exerts its antiallodynic effects on neuropathic pain via descending 5-HT fibers and spinal 5-HT2A or 5-HT2C receptors, and the antinociception on acute mechanical pain via 5-HT3 receptors. | Fluvoxamine | 5-hydroxytryptamine (serotonin) receptor 2A | Mus musculus |