Title : Various cytosine/adenine permease homologues are involved in the toxicity of 5-fluorocytosine in Saccharomyces cerevisiae.

Pub. Date : 2006 Jul 15

PMID : 16845689






1 Functional Relationships(s)
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1 By applying a highly sensitive assay, a low-level but dose-dependent toxicity of 5-FC in fcy2 mutants was detected, whereas cells deficient in the cytosine deaminase (encoded by FCY1), which is essential for intracellular conversion of 5-FC to 5-fluorouracil, display strong dose-independent resistance. Flucytosine cytosine deaminase Saccharomyces cerevisiae S288C