Title : Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1.

Pub. Date : 2006

PMID : 16845181






4 Functional Relationships(s)
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1 Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-kappaB, and AP-1. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 The aim of this study was to determine the effect of nicotine on the expression of the adhesion molecules, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in endothelial cells and to determine the involvement of important known intermediaries, protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and the transcription factors NF-kappaB and AP-1. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Nicotine (10-8 mol/L) also increased NF-kappaB and AP-1 activity. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
4 Our results indicate that nicotine enhances the expression of ICAM-1 and VCAM-1 on the endothelial cell surface via a second messenger pathway which involves PKC and p38 MAPK-mediated activation of NF-kappaB and AP-1, resulting in increased expression of these cellular adhesion molecules. Nicotine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens