Title : Screening for caspase-3 inhibitors: effect of a reducing agent on identified hit chemotypes.

Pub. Date : 2006 Sep

PMID : 16844966






1 Functional Relationships(s)
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1 While screening a library of small molecules against caspase-3, the authors have found that the nature of the reducing agent used, DTT or beta-MCE, dramatically affects screening results and leads to identification of nonoverlapping hits. Dithiothreitol caspase 3 Homo sapiens