Title : Development of a stickleback kidney cell culture assay for the screening of androgenic and anti-androgenic endocrine disrupters.

Pub. Date : 2006 Aug 23

PMID : 16843539






1 Functional Relationships(s)
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1 The anabolic steroid 17beta-Trenbolone (TB) was able to stimulate spiggin synthesis in a concentration-dependent manner with a significant effect at a concentration as low as 10(-10)M, and a maximal effect at 10(-6)M. The synthetic human androgen receptor antagonist, flutamide had no effect alone, but concentration-dependently inhibited the stimulatory effect of 10(-8)M 11-KT with a complete inhibition at 10(-6)M flutamide. Steroids androgen receptor Homo sapiens