Title : Intestinal tract injury by drugs: Importance of metabolite delivery by yellow bile road.

Pub. Date : 2006 Dec

PMID : 16842856






2 Functional Relationships(s)
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1 Observations from clinical and experimental studies have defined key events in the pathogenesis of these drugs, including roles for multidrug resistance-associated protein 2 (MRP2) and other transporters in biliary secretion and adduction of enterocyte proteins by reactive acyl glucuronide metabolites as a likely mechanism for intestinal injury. Glucuronides ATP binding cassette subfamily C member 2 Homo sapiens
2 Observations from clinical and experimental studies have defined key events in the pathogenesis of these drugs, including roles for multidrug resistance-associated protein 2 (MRP2) and other transporters in biliary secretion and adduction of enterocyte proteins by reactive acyl glucuronide metabolites as a likely mechanism for intestinal injury. Glucuronides ATP binding cassette subfamily C member 2 Homo sapiens