Title : Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes.

Pub. Date : 2006 Aug 15

PMID : 16835262






3 Functional Relationships(s)
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1 Mutations resulting in the expansion of a polyglutamine tract in the protein ataxin-2 give rise to the neurodegenerative disorders spinocerebellar ataxia type 2 and Parkinson"s disease. polyglutamine Ataxin-2 Drosophila melanogaster
2 The normal cellular function of ataxin-2 and the mechanism by which polyglutamine expansion of ataxin-2 causes neurodegeneration are unknown. polyglutamine Ataxin-2 Drosophila melanogaster
3 Our results raise the possibility that polyglutamine expansions within ataxin-2 cause neurodegeneration by interfering with the translational regulation of particular mRNAs. polyglutamine Ataxin-2 Drosophila melanogaster