Pub. Date : 2006 Aug 15
PMID : 16835262
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutations resulting in the expansion of a polyglutamine tract in the protein ataxin-2 give rise to the neurodegenerative disorders spinocerebellar ataxia type 2 and Parkinson"s disease. | polyglutamine | Ataxin-2 | Drosophila melanogaster |
| 2 | The normal cellular function of ataxin-2 and the mechanism by which polyglutamine expansion of ataxin-2 causes neurodegeneration are unknown. | polyglutamine | Ataxin-2 | Drosophila melanogaster |
| 3 | Our results raise the possibility that polyglutamine expansions within ataxin-2 cause neurodegeneration by interfering with the translational regulation of particular mRNAs. | polyglutamine | Ataxin-2 | Drosophila melanogaster |