Title : C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.

Pub. Date : 2006 Aug 15

PMID : 16828468






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 pyr-1 encodes CAD, a trifunctional enzyme required for de novo pyrimidine synthesis, and pyr-1(cu8) mutants are rescued by supplying exogenous pyrimidines. pyrimidine Glutamine-dependent carbamoyl-phosphate synthase Caenorhabditis elegans
2 rib-1 mutant lethality was enhanced in a pyr-1 mutant background, indicating that HSPG synthesis is very sensitive to decreased pyrimidine pools, and HS disaccharides are moderately decreased in both rib-1 and pyr-1 mutants. pyrimidine Glutamine-dependent carbamoyl-phosphate synthase Caenorhabditis elegans