Title : X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.

Pub. Date : 2006 Jul 1

PMID : 16820676






1 Functional Relationships(s)
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1 The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. Sulfonamides carbonic anhydrase 2 Homo sapiens