Pub. Date : 2006 Aug 15
PMID : 16817206
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using cocultures of rat cortical neurons and microglia, we show that ATP and the more potent P2X(7) agonist benzoylbenzoyl-ATP (BzATP) cause neuronal cell injury. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 2 | Using cocultures of rat cortical neurons and microglia, we show that ATP and the more potent P2X(7) agonist benzoylbenzoyl-ATP (BzATP) cause neuronal cell injury. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 3 | The deleterious effects of BzATP-treated microglia were prevented by nonselective P2X antagonists (PPADS and oxidized ATP) and by the more selective P2X(7) antagonist Brilliant Blue G. Similar concentrations of BzATP caused release of superoxide and nitric oxide from isolated microglia, and neuronal cell injury was attenuated by a superoxide dismutase mimetic and by a peroxynitrite decomposition catalyst, suggesting a role for reactive oxide species. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |