Title : The calcium channel blocker amlodipine promotes the unclamping of eNOS from caveolin in endothelial cells.

Pub. Date : 2006 Aug 1

PMID : 16814758






1 Functional Relationships(s)
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1 Here, we reasoned that since the endothelial nitric oxide synthase is, in part, expressed in cholesterol-rich plasmalemmal microdomains (e.g., caveolae and rafts), amlodipine could interfere with this specific locale of the enzyme and thereby modulate NO production in endothelial cells. Cholesterol nitric oxide synthase 3 Homo sapiens