Pub. Date : 2006 Jan-Feb
PMID : 16809218
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxycycline decreases monocyte chemoattractant protein-1 in human lung epithelial cells. | Doxycycline | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | The authors hypothesized that doxycycline exerts its anti-inflammatory effects, in part, by reducing MCP-1 production. | Doxycycline | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | In stimulated cells doxycycline decreased MCP-1 production by 95% and in monocyte chemotaxis assays migration decreased by 55%. | Doxycycline | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | However, doxycycline did decrease expression of MCP-1 mRNA and did not effect its stability. | Doxycycline | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | These data demonstrate that doxycycline modulates MCP-1 production and suggest that doxycycline may provide a new anti-inflammatory therapy for chronic lung diseases. | Doxycycline | C-C motif chemokine ligand 2 | Homo sapiens |