Title : Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats.

Pub. Date : 2006 Jul

PMID : 16805961






1 Functional Relationships(s)
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1 Because both drugs are transported via P-glycoprotein and breast cancer resistance protein and metabolized by cytochrome P450 3A2, the interaction of imatinib mesilate with these proteins may be responsible for the increased intestinal absorption of ciclosporin in rats. Imatinib Mesylate ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus