Pub. Date : 2006 Aug
PMID : 16803598
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported that azole-resistant mutants (MIC >or= 64 microg ml(-1)) of strain 66032 (MIC = 16 microg ml(-1)) similarly show coordinate CDR1-PDH1 upregulation, and in one of these (F15) a putative gain-of-function mutation was identified in the single homologue of Saccharomyces cerevisiae transcription factors Pdr1-Pdr3. | Azoles | drug-responsive transcription factor PDR1 | Saccharomyces cerevisiae S288C |
| 2 | Reintroduction of wild-type or F15 PDR1 fully reversed these effects; together these results demonstrate a role for this gene in both acquired and intrinsic azole resistance. | Azoles | drug-responsive transcription factor PDR1 | Saccharomyces cerevisiae S288C |
| 3 | In an azole-resistant clinical isolate, PDR1 disruption reduced azole MICs eight- to 64-fold with no effect on sensitivity to other antifungals. | Azoles | drug-responsive transcription factor PDR1 | Saccharomyces cerevisiae S288C |
| 4 | In an azole-resistant clinical isolate, PDR1 disruption reduced azole MICs eight- to 64-fold with no effect on sensitivity to other antifungals. | Azoles | drug-responsive transcription factor PDR1 | Saccharomyces cerevisiae S288C |