Title : Vasoactive intestinal peptide stimulates catecholamine biosynthesis in isolated adrenal chromaffin cells: evidence for a cyclic AMP-dependent phosphorylation and activation of tyrosine hydroxylase.

Pub. Date : 1991 Oct

PMID : 1680163






3 Functional Relationships(s)
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1 Vasoactive intestinal peptide (VIP) increased catecholamine biosynthesis in bovine adrenal chromaffin cells by 50-200%. Catecholamines vasoactive intestinal peptide Bos taurus
2 VIP led to an elevation of cyclic AMP levels, and this increase occurred over a similar concentration range and time course as the activation of TH and the increase in catecholamine biosynthesis. Catecholamines vasoactive intestinal peptide Bos taurus
3 Our results indicate that VIP stimulates catecholamine biosynthesis in chromaffin cells through the phosphorylation and activation of TH and support the conclusion that a cyclic AMP-dependent phosphorylation of TH is responsible for these effects. Catecholamines vasoactive intestinal peptide Bos taurus