Title : Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state.

Pub. Date : 2006 Jul 4

PMID : 16800628






1 Functional Relationships(s)
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1 Using established methods involving ADP-Vi trapping by wild-type Pgp and ATP binding by catalytic carboxylate mutant Pgp, these effects can be extended to ATP hydrolysis transition-state stabilization and ATP occlusion at a single site. carboxylate ATP binding cassette subfamily B member 1 Homo sapiens