Pub. Date : 2006 Jun
PMID : 16794859
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High glutamate decreases S100B secretion by a mechanism dependent on the glutamate transporter. | Glutamic Acid | S100 calcium binding protein B | Homo sapiens |
| 2 | Extracellular S100B protects hippocampal neurons from excitotoxic damage, whilst toxic levels of glutamate to neurons have been shown to reduce S100B secretion in astrocytes and brain slices, by an unknown mechanism. | Glutamic Acid | S100 calcium binding protein B | Homo sapiens |
| 3 | DCG-IV, an agonist of group II metabotropic glutamate receptors, caused a smaller decrease in S100B secretion when compared to 1 mM glutamate. | Glutamic Acid | S100 calcium binding protein B | Homo sapiens |
| 4 | D: -aspartate partially reverted the glutamate effect on S100B release and two other inhibitors, PDC and DIDS, reverted it completely. | Glutamic Acid | S100 calcium binding protein B | Homo sapiens |
| 5 | These findings suggest that S100B secretion is inversely coupled to glutamate uptake. | Glutamic Acid | S100 calcium binding protein B | Homo sapiens |