Title : Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-Jun terminal NH2 kinase activation.

Pub. Date : 2006 Jul 21

PMID : 16794185






2 Functional Relationships(s)
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1 Paclitaxel potently activated c-Jun terminal NH2 kinase (JNK) as compared with thrombin alone, whereas the thrombin-mediated phosphorylation of p38 and extracellular signal-regulated kinase remained unaffected. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
2 Paclitaxel increases endothelial TF expression via its stabilizing effect on microtubules and selective activation of JNK. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens