Pub. Date : 2006 Sep
PMID : 16788089
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase. | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |
| 2 | Using human platelets, we explored the molecular mechanisms underlying the boswellic acid-induced release of arachidonic acid and the subsequent metabolism by platelet-type 12-li-poxygenase (p12-LO). | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |
| 3 | Using human platelets, we explored the molecular mechanisms underlying the boswellic acid-induced release of arachidonic acid and the subsequent metabolism by platelet-type 12-li-poxygenase (p12-LO). | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |
| 4 | It is noteworthy that in cell-free assays, beta-boswellic acid increased p12-LO catalysis approximately 2-fold in the absence but not in the presence of Ca2+, whereas AKBA inhibited p12-LO activity. | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |
| 5 | Taken together, we show that boswellic acids induce the release of arachidonic acid and the synthesis of 12-H(P)ETE in human platelets by unique Ca2+-independent routes, and we identified p12-LO as a selective molecular target of boswellic acids. | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |
| 6 | Taken together, we show that boswellic acids induce the release of arachidonic acid and the synthesis of 12-H(P)ETE in human platelets by unique Ca2+-independent routes, and we identified p12-LO as a selective molecular target of boswellic acids. | boswellic acid | arachidonate 12-lipoxygenase, 12S type | Homo sapiens |