Title : Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

Pub. Date : 2006 Jun 28

PMID : 16787097






1 Functional Relationships(s)
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Protein Name
Organism
1 Its binding to hCA II is similar to that of other benzesulfonamides, with the ionized sulfonamide coordinated to the Zn2+ ion within the enzyme active site, and also participating in a network of hydrogen bonds with residues Thr199 and Glu106. Sulfonamides carbonic anhydrase 2 Homo sapiens