Pub. Date : 2006 Oct
PMID : 16783693
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The cytotoxicity of the alkaloid emetine was determined in six human cell lines that differ in the expression of ABC transporters, such as multiple drug resistance protein 1 (MDR1/ABCB1) and multidrug resistance associated protein 1 (MRP1/ABCC1). | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The cytotoxicity of the alkaloid emetine was determined in six human cell lines that differ in the expression of ABC transporters, such as multiple drug resistance protein 1 (MDR1/ABCB1) and multidrug resistance associated protein 1 (MRP1/ABCC1). | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Emetine reveals a substantial cytotoxicity due to apoptosis that is inversely correlated with the expression of MDR1. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Apparently emetine is a substrate for MDR1 but not for MRP1. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | Furthermore, emetine is able to up-regulate the expression of MDR1 as shown IN VITRO by real-time PCR and transport activity studies. | Emetine | ATP binding cassette subfamily B member 1 | Homo sapiens |