Title : PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors.

Pub. Date : 2006 Sep

PMID : 16782779






2 Functional Relationships(s)
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1 Since we have previously shown that tumor promotion by PB leads to clonal outgrowth of beta-catenin (Catnb)-mutated but not Ha-ras-mutated mouse liver tumors, we were interested to know whether the non-dioxin-like tumor promoter 2,2",4,4",5,5"-hexachlorobiphenyl (PCB 153) shows the same selective pressure during tumor promotion. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus
2 Since we have previously shown that tumor promotion by PB leads to clonal outgrowth of beta-catenin (Catnb)-mutated but not Ha-ras-mutated mouse liver tumors, we were interested to know whether the non-dioxin-like tumor promoter 2,2",4,4",5,5"-hexachlorobiphenyl (PCB 153) shows the same selective pressure during tumor promotion. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus