Pub. Date : 2006 Jun 18
PMID : 16778968
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | High glucose medium induced phosphorylation of ERK1/2 at as early as minute 30, reached the peak at hour 6; maintained the activity at hours 12 and 24, and declined to the basal level at hour 48. | Glucose | mitogen-activated protein kinase 3 | Mus musculus |
2 | Blockade of phosphorylation of ERK1/2 with PD98059, a specific ERK1/2 activation inhibitor, did decrease the high glucose-triggered expression of CTGF protein in 4 days. | Glucose | mitogen-activated protein kinase 3 | Mus musculus |
3 | Blockade of phosphorylation of ERK1/2 with PD98059, a specific ERK1/2 activation inhibitor, did decrease the high glucose-triggered expression of CTGF protein in 4 days. | Glucose | mitogen-activated protein kinase 3 | Mus musculus |
4 | CONCLUSION: Acute high glucose (2-4 days) stimulated the expression of CTGF protein via ERK1/2-dependent signaling pathway in cultured podocytes, while cultured in high glucose for 6-8 days, the podocytes did not increase its CTGF level. | Glucose | mitogen-activated protein kinase 3 | Mus musculus |