Title : Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine.

Pub. Date : 1991 Jul

PMID : 1677450






1 Functional Relationships(s)
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1 No change was noted in the intracellular concentration of the corresponding physiological deoxynucleoside-5"-triphosphate, dATP; positive correlation was observed, however, between the increase in ddATP formation from ddIno and the increase in intracellular IMP occurring as a consequence of IMPD inhibition. Inosine Monophosphate inosine monophosphate dehydrogenase 1 Homo sapiens