Title : Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds.

Pub. Date : 2006 May

PMID : 16771648






1 Functional Relationships(s)
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1 Enhanced metabolizing activity of CYP3A4, measured by the amount 6beta-testosterone formed from testosterone, and that of the phase II enzyme glucuronosyltransferases (UGT) further indicated that the tissue-engineered C3A spheroids may provide an efficient experimental tool for predicting drug activities by these CYPs. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens