Title : Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions.

Pub. Date : 1991 Jul 15

PMID : 1676967






1 Functional Relationships(s)
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1 All three isozymes were rapidly activated (13-40-fold) by incubation with Fe(II) salts (concentration of iron at half-maximal activation = 6-14 microM), and were inhibited by other divalent metal ions, e.g. Zn(II), Co(II) and Ni(II). ammonium ferrous sulfate mitochondrially encoded cytochrome c oxidase II Homo sapiens