Title : Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

Pub. Date : 1991 Jun

PMID : 1676428






1 Functional Relationships(s)
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1 Among the novel tyrphostins examined we found inhibitors which discriminate between the highly homologous EGF receptor kinase (HER1) and ErbB2/neu kinase (HER2). Tyrphostins epidermal growth factor receptor Homo sapiens