Title : The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics.

Pub. Date : 2006 Aug 18

PMID : 16762915






1 Functional Relationships(s)
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Protein Name
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1 In substrate-free CYP3A4, the oxy complex is extremely unstable with a half-life of approximately 30 ms at 5 degrees C. Saturation with testosterone or bromocriptine stabilizes the oxy-ferrous intermediate. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens